Diabetes research requires the use of insulin-secreting islets of Langerhans that are derived from the pancreas of a human or a mouse. Islets of Langerhans are tiny cell clusters in the pancreas that are responsible for insulin production. When these cells malfunction, diabetes occurs. Whole islets, or the beta cells derived from islets, are a critical component in diabetes research. For example, they are required when using high-throughput screens (HTS) to identify the next active compound that would lead to an increase in newly-formed beta-cells or to reduce the chance of beta-cell death. Unfortunately, isolation of islets from donor tissues is a technically challenging process, which limits the number of islets available from the individual donor. Also, it is often complicated by the lack of access to donor pancreas tissue.